JPS5965018A - 消化器潰瘍治療予防剤 - Google Patents
消化器潰瘍治療予防剤Info
- Publication number
- JPS5965018A JPS5965018A JP57175659A JP17565982A JPS5965018A JP S5965018 A JPS5965018 A JP S5965018A JP 57175659 A JP57175659 A JP 57175659A JP 17565982 A JP17565982 A JP 17565982A JP S5965018 A JPS5965018 A JP S5965018A
- Authority
- JP
- Japan
- Prior art keywords
- component
- agent
- treating
- ulcer
- cinnamon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000008469 Peptic Ulcer Diseases 0.000 title 1
- 208000011906 peptic ulcer disease Diseases 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 235000017803 cinnamon Nutrition 0.000 claims description 6
- 206010061459 Gastrointestinal ulcer Diseases 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 230000003449 preventive effect Effects 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 241000723347 Cinnamomum Species 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 description 12
- 231100000397 ulcer Toxicity 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 238000000034 method Methods 0.000 description 8
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 8
- 239000002504 physiological saline solution Substances 0.000 description 7
- 210000001187 pylorus Anatomy 0.000 description 5
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 4
- 206010042220 Stress ulcer Diseases 0.000 description 4
- 208000000718 duodenal ulcer Diseases 0.000 description 4
- 230000002496 gastric effect Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 229940076279 serotonin Drugs 0.000 description 4
- 240000007594 Oryza sativa Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 102000057297 Pepsin A Human genes 0.000 description 3
- 108090000284 Pepsin A Proteins 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 238000005194 fractionation Methods 0.000 description 3
- 230000027119 gastric acid secretion Effects 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 229940111202 pepsin Drugs 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 241000700157 Rattus norvegicus Species 0.000 description 2
- 210000001015 abdomen Anatomy 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000008645 cold stress Effects 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 230000002008 hemorrhagic effect Effects 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 244000175448 Citrus madurensis Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000017317 Fortunella Nutrition 0.000 description 1
- 241000218195 Lauraceae Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- WUKZPHOXUVCQOR-UHFFFAOYSA-N N-(1-azabicyclo[2.2.2]octan-3-yl)-6-chloro-4-methyl-3-oxo-1,4-benzoxazine-8-carboxamide Chemical compound C1N(CC2)CCC2C1NC(=O)C1=CC(Cl)=CC2=C1OCC(=O)N2C WUKZPHOXUVCQOR-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000000767 anti-ulcer Effects 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 239000012223 aqueous fraction Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
- 229940017545 cinnamon bark Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- CRVGKGJPQYZRPT-UHFFFAOYSA-N diethylamino acetate Chemical compound CCN(CC)OC(C)=O CRVGKGJPQYZRPT-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- -1 ethyl ethyl Chemical group 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000001965 increasing effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57175659A JPS5965018A (ja) | 1982-10-05 | 1982-10-05 | 消化器潰瘍治療予防剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57175659A JPS5965018A (ja) | 1982-10-05 | 1982-10-05 | 消化器潰瘍治療予防剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5965018A true JPS5965018A (ja) | 1984-04-13 |
| JPS626689B2 JPS626689B2 (en]) | 1987-02-13 |
Family
ID=15999963
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57175659A Granted JPS5965018A (ja) | 1982-10-05 | 1982-10-05 | 消化器潰瘍治療予防剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5965018A (en]) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888417A (en) * | 1985-05-25 | 1989-12-19 | Green Cross Corporation | Therapeutic and prophylactic agents for peptic ulcer |
| WO2012120475A1 (en) | 2011-03-09 | 2012-09-13 | Pt. Dexa Medica | Cinnamomum burmanii extract, extraction process and its use as proton pump down-regulator, enzyme inhibitor, and mucoprotector |
| JP2020504144A (ja) * | 2017-01-11 | 2020-02-06 | チョン クン ダン ファーマシューティカル コーポレーション | 胃炎または消化性潰瘍予防または治療用組成物 |
-
1982
- 1982-10-05 JP JP57175659A patent/JPS5965018A/ja active Granted
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888417A (en) * | 1985-05-25 | 1989-12-19 | Green Cross Corporation | Therapeutic and prophylactic agents for peptic ulcer |
| US5053498A (en) * | 1985-05-25 | 1991-10-01 | Green Cross Corporation | Therapeutic and prophylactic agents for peptic ulcer |
| WO2012120475A1 (en) | 2011-03-09 | 2012-09-13 | Pt. Dexa Medica | Cinnamomum burmanii extract, extraction process and its use as proton pump down-regulator, enzyme inhibitor, and mucoprotector |
| JP2014508774A (ja) * | 2011-03-09 | 2014-04-10 | ペルセロアン・テルバタス デキサ・メディカ | ジャワニッケイの抽出物、抽出方法、ならびにプロトンポンプダウンレギュレーター、酵素阻害剤および粘膜保護剤としてのそれの使用 |
| EP2683392A4 (en) * | 2011-03-09 | 2014-12-03 | Pt Dexa Medica | CINNAMOMUM BURMANII EXTRACT, EXTRACTION METHOD AND ITS USE AS PROTONAL PUMP DOWNWARD CONTROL, ENZYME HUMAN AND MUCOPROTECTOR |
| AU2012226374B2 (en) * | 2011-03-09 | 2016-11-17 | Pt. Dexa Medica | Cinnamomum burmanii extract, extraction process and its use as proton pump down-regulator, enzyme inhibitor, and mucoprotector |
| JP2020504144A (ja) * | 2017-01-11 | 2020-02-06 | チョン クン ダン ファーマシューティカル コーポレーション | 胃炎または消化性潰瘍予防または治療用組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS626689B2 (en]) | 1987-02-13 |
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